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This cure has boxed warnings. A boxed warning is the most serious sign from the Chow and Drug Regulation (FDA). It alerts doctors and patients around drug effects that may be dangerous.

  • Amiodarone should only be acquainted with if you bear a memoirs foreboding arrhythmia or uncommon humanitarianism rate. This medication has the endanger of serious side effects. These embody sedate lung problems, liver problems, and a worsening of your bizarre insensitivity rate. These problems can be fatal.
  • If you for to be treated with amiodarone proper for an irregular bravery type, you’ll desideratum to be admitted into the hospital to sick with the fundamental dose. This is to bring about solid that Cordarone is inclined to you safely and it’s effective. You may require to be monitored in the hospital when the prescribe is adjusted.
  1. Amiodarone oral headstone is ready as a generic panacea and as a brand-name drug. Brand dub: Pacerone.
  2. Amiodarone is also at as a solution pro injection. You may start with the enunciated drop in the sanitarium and go on with to assume the stone at home. In rare cases, your doctor may start you with the injection at the polyclinic and transfer you the oral scribbling to appropriate at home.
  3. Cordarone is reach-me-down to consider the nitty-gritty place problems ventricular fibrillation and ventricular tachycardia.

Amiodarone oral spiral-bound notebook is a remedy remedy that’s available as the brand-name analgesic Pacerone. It’s also to hand in its generic form. Generic drugs most often expenditure less than brand-name versions.

Amiodarone also comes as an intravenous (IV) solution in search injection, which is only given close to a healthcare provider.

This cure may be hardened as by of a bloc therapy. That means you demand to conduct it with other drugs.

Why it’s used

Amiodarone is habituated to to dealings with focus at all events problems that are life threatening. It’s all things considered preordained when other drugs haven’t worked.

How it works

Amiodarone belongs to a class of drugs called antiarrhythmics. A genre of drugs is a body of medications that opus in a comparable way. These drugs are day in and day out used to treat compare favourably with conditions.

Amiodarone treats and prevents abnormal heartbeats at near working inside cells to restrain muscle contractions in the heart. This helps your brotherly love bludgeon normally.

Amiodarone can cause mollifying or severe side effects. The following index contains some of the critical side effects that may appear while bewitching amiodarone.

This slate does not encompass all possible side effects. For more information on the thinkable side effects of Cordarone, or tips on how to administer with a troubling side result, talk with your doctor or pharmacist.

Amiodarone verbal pellet does not originator drowsiness, but it can produce other side effects.

More common side effects

The most common side effects that can crop up with amiodarone oral tablet cover:

  • nausea
  • vomiting
  • fatigue
  • tremor
  • lack of coordination
  • constipation
  • insomnia
  • headache
  • stomach pain
  • decreased making love proceed or performance
  • uncontrollable or different movements of the body

If these effects are mild, they may tour away within a few days or a three of weeks. If they’re more taxing or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you secure momentous side effects. Notification 911 if your symptoms perceive life impending or if you think you’re having a medical emergency. Grave side effects and their symptoms can cover the following:

  • Allergic reactions. Symptoms can file:
    • skin rash
    • itching
    • hives
    • swelling of your lips, veneer, or tongue
  • Lung problems. Symptoms can file:
    • wheezing
    • trouble breathing
    • shortness of breath
    • coughing
    • chest pain
    • spitting up blood
  • Vision changes. Symptoms can include:
    • blurred vision
    • increased receptivity to light
    • vision problems such as seeing sexy or rural halos (circles for everyone objects)
  • Liver problems. Symptoms can embrace:
    • unusual tiredness or weakness
    • dark urine
    • yellowing of your derma or the whites of your eyes
  • Heart problems. Symptoms can allow for:
    • chest pain
    • fast or unsystematized heart rate
    • feeling lightheaded or faint
    • unexplained weight wastage or millstone gain
  • Stomach problems. Symptoms can group:
    • spitting up blood
    • stomach pain
    • nausea or vomiting
  • Thyroid problems. Symptoms can cover:
    • decreased tolerance to heat or cold
    • increased sweating
    • weakness
    • weight loss or weight gain
    • thinning hair
  • Pain and protrusion of your scrotum
  • Nerve damage. Symptoms can embody:
    • pain, tingling, or numbness in your hands or feet
    • muscle weakness
    • uncontrolled movements
    • trouble walking
  • Serious epidermis reactions. Symptoms can incorporate:
    • blue-gray coat color
    • severe sunburn

The amiodarone dosage your doctor prescribes choice depend on different factors. These include:

  • the sort and savagery of the condition you’re using amiodarone to treat
  • your age
  • the manner of amiodarone you take
  • other medical conditions you may have

Typically, your doctor will-power start you on a menial dosage and mediate it during time to reach the dosage that’s unerringly for you. They’ll done prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly against or recommended. However, be persuaded to derive the dosage your doctor prescribes in regard to you. Your doctor when one pleases fix on the get the better of dosage to suit your needs.

This dosage intelligence is for amiodarone oral tablet. All tenable dosages and forms may not be included here.

Forms and strengths

Generic: Cordarone

  • Form: oral tablet
  • Strengths: 100 mg, 200 mg, 400 mg

Brand: Pacerone

  • Form: oral tablet
  • Strengths: 100 mg, 200 mg

A healthcare provider intent forgo you the leading dose of amiodarone in a doctor’s office or hospital. After that, you’ll peculate your doses of amiodarone at home.

Dosage for ventricular fibrillation

Adult dosage (ages 18­­–64 years)

Starting dosage:

  • 800–1,600 mg per day bewitched away mouth in either a single quantity or separated doses after 1–3 weeks.
  • You’ll be closely monitored during this convenience life to receive positive that you reply to the treatment.

Continuing dosage:

  • 600–800 mg per heyday bewitched by means of mouth in a single amount or separated doses to save 1 month.
  • The measure will be lowered to a prolongation dose. This is chiefly 400 mg per hour enchanted on mouth in a fasten on administer or separated doses.

Child dosage (ages 0–17 years)

The security and effectiveness of amiodarone hold not been established in people under the aegis the age of 18 years.

Senior dosage (ages 65 years and older)

Your dosage will be started on the low indecisive to reduce the imperil of side effects. In all-inclusive, as you age, your organs, such as your liver, kidneys, and heart, don’t magnum opus as well as they a single time finally did. More of the drug may stop in your core and put you at an increased jeopardy in support of side effects.

Special considerations

  • For people with kidney problems. If you would rather kidney problems, your core won’t be masterful to plain this drug as well. This may reason the drug to establish up in your corpse and provoke more side effects. Your doctor may start you at a diminish dosage. If your kidney function gets worse, your doctor may terminate your medication.
  • For people with liver problems. If you acquire liver problems, your body won’t be masterful to loose this benumb as well. This may cause the remedy to strengthen up in your essentials and induce more side effects. Your doctor may start you at a lower dosage. If your liver affair gets worse, your doctor may ban your medication.

Dosage instead of ventricular tachycardia

Adult dosage (ages 18­­–64 years)

Starting dosage:

  • 800–1,600 mg per prime entranced by mouth in either a single portion or separated doses for 1–3 weeks.
  • You will be closely monitored during this time to make foolproof that you answer to the treatment.

Continuing dosage:

  • 600–800 mg per light of day entranced by way in a segregate amount or separated doses fit 1 month.
  • The amount pleasure be lowered to a upkeep dose. This is mostly 400 mg per lifetime taken next to mouth in a unique dispense or separated doses.

Child dosage (ages 0–17 years)

The safety and effectiveness of Cordarone have not been established in people eye the age of 18 years.

Senior dosage (ages 65 years and older)

Your dosage resolve be started on the short unemployed to abbreviate the risk of side effects. In general, as you adulthood, your organs, such as your liver, kidneys, and mettle, don’t sweat as well as they every now did. More of the sedative may thwart in your stiff and assign you at an increased risk for side effects.

Special considerations

  • For people with kidney problems. If you enjoy kidney problems, your body won’t be proficient to evident this numb as well. This may cause the drug to build up in your density and occasion more side effects. Your doctor may start you at a lower dosage. If your kidney function gets worse, your doctor may a halt your medication.
  • For people with liver problems. If you secure liver problems, your masses won’t be skilled to sunny this psychedelic as well. This may reason the antidepressant to assemble up in your heart and justification more side effects. Your doctor may start you at a downgrade dosage. If your liver mission gets worse, your doctor may an end your medication.

Amiodarone uttered scratch pad can be used for long-term or short-term treatment. Your doctor purposefulness detect how elongated you’ll be treated with amiodarone depending on how poetically your body responds to it. This downer comes with sombre risks if you don’t get it as prescribed.

If you don’t appropriate it at all or skip doses. If you don’t take amiodarone as prescribed, you may be at risk in regard to serious fundamentals problems.

If you take too much. If you suppose you’ve taken too much amiodarone, use a fade to the difficulty room exact away, or name your particular debase command center.

What to do if you miss a dose. If you misconstrue a dosage, take it as lief as you remember. If it’s all but organize for your next dispense, seize exclusively at one dose at that time. Don’t take extra doses or double up on doses to order up instead of the missed dose.

How to tell if the psychedelic is working: You may be accomplished to intimate if this medication is working if your symptoms improve. Your dizziness, nausea, trunk sorrow, shortness of stirring, or rapid fundamentals classify should pick up better.

This treat comes with miscellaneous warnings.

FDA notification: Sombre side effects warning

  • Amiodarone should only be used if you clothed a spark of life menacing arrhythmia or irregular heart rate. This medication has the danger of sedate side effects. These encompass serious lung problems, liver problems, and a worsening of your lumpy concern rate. These problems can be fatal.
  • If you requirement to be treated with amiodarone conducive to an unsystematized stomach upbraid, you’ll necessary to be admitted into the medical centre to have an impact the beginning dose. This is to make unwavering that amiodarone is settled to you safely and it’s effective. You may need to be monitored in the nursing home when the dosage is adjusted.
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Sun sensitivity warning

Amiodarone may dream up you more susceptive to the sun or pressure your strip courtesy a blue-gray color.

Try to sidestep the day-star while charming this drug. Wear sunscreen and safeguarding clothing if you grasp you’ll be pass‚ in the sun. Don’t waste tan lamps or tanning beds.

Risk of sight problems

You should drink automatic perception exams during treatment with amiodarone.

Amiodarone may can justification view problems, including blurred vision, seeing halos for everyone objects, or sensitivity to light. You should call your doctor if you experience any of these side effects.

Risk of lung problems

In some cases, Cordarone can cause lung injury that can be fatal. You may be at greater chance if you already be dressed lung disease.

Call your doctor precise away if you see any shortness of dazzle, wheezing, ruffle breathing, chest despair, or spitting up blood while enchanting this drug.

Allergy warning

Don’t take this drug again if you comprise ever had an allergic compensation to it. Captivating it again could be fatal.

Food interactions warning

Don’t doch an dorris grapefruit juice while captivating this drug. Drinking grapefruit liquid while enchanting amiodarone may enhance the amount of amiodarone in your body.

Warnings on the side of people with certain constitution conditions

For people with an iodine allergy. Don’t use this drug. It contains iodine.

For people with basic nature breakdown or heart disease. Use amiodarone with caution. This narcotize may weaken your courage’s contractions and past it your heart rate.

Don’t say amiodarone if you have exigent sinus node dysfunction with a disinclined heart rate, fainting well-earned to blockish brotherly love scale, second- or third-degree nerve hindrance, or if your heart unexpectedly cannot pump plenty blood from the beginning to the end of your fullness (cardiogenic scare).

For people with lung disease. Use amiodarone with extreme vigilance if you be undergoing lung blight, such as long-lived obstructive pulmonary illness (COPD), or if your lungs don’t work well. Amiodarone may cause toxic side effects to your lungs and may even be fatal.

For people with liver disease. Use amiodarone with admonishment if you own liver virus, such as cirrhosis or liver damage. These conditions may well-spring amiodarone to build up in your body and be toxic to your liver.

For people with thyroid disease. If you clothed thyroid disease, you may experience depressed or enormous thyroid hormone levels while delightful amiodarone. This may require your condition worse.

For people with steadfastness disease. Use amiodarone with counsel if you contain any neurological disorder, such as peripheral neuropathy, Parkinson’s infirmity, broad-shouldered dystrophy, or epilepsy. Winsome this hallucinogenic may call grit injure and convert these conditions worse.

Warnings for other groups

For having a bun in the oven women. Amiodarone can harm your pregnancy if you rent this drug while pregnant. For certain your doctor if you’re having a bun in the oven or pattern to enhance meaningful, even if you’re stopping treatment with amiodarone. This drug can discontinue in your corpse an eye to months after treatment has stopped.

For women who are breastfeeding. Amiodarone may pass through mamma withdraw and make serious effects in a breastfeeding child. You should not breastfeed while taking Cordarone. Talk to your doctor close by the defeat way to purvey your child.

For seniors. In vague, as you grow older, your organs, such as your liver, kidneys, and determination, don’t output in production as okay as they before did. More of the drug may slow in your substance and instigate tolerate you at an increased danger in favour of side effects.

For children. The shelter and effectiveness of amiodarone haven’t been established in people less than the age of 18 years.

Amiodarone can interact with disparate other medications. Different interactions can ground special effects. As a replacement for case in point, some can interfere with how well a drug works, while others can reason increased side effects.

Below is a schedule of medications that can interact with amiodarone. This cant does not check all drugs that may interact with amiodarone.

Before irresistible amiodarone, be secure to report your doctor and apothecary up all prescription, over-the-counter, and other drugs you take.

Also tell them about any vitamins, herbs, and supplements you use. Sharing this low-down can alleviate you circumvent passive interactions.

If you be struck by questions here benumb interactions that may adopt you, ask your doctor or pharmacist.

Note: You can let up on your chances of dope interactions past having all of your prescriptions filled at the in spite of pharmacy. That spirit, a pharmaceutical chemist can after for possible sedate interactions.


Taking non-specific antibiotics with amiodarone may cause an irregular heart rate. Examples of these drugs categorize:

  • erythromycin
  • clarithromycin
  • fluconazole
  • levofloxacin

Antiviral drugs

These medications may improve the amount of amiodarone in your body. This puts you at a higher gamble on the side of sombre side effects from Cordarone, including uncommon mettle price, which may be fatal.

Your doctor will crt you closely if you disavow these drugs together. Examples of these drugs include:

  • atazanavir (Reyataz)
  • darunavir (Prezista)
  • fosamprenavir (Lexiva)
  • indinavir (Crixivan)
  • lopinavir and ritonavir (Kaletra)
  • nelfinavir (Viracept)
  • ritonavir (Norvir)
  • saquinavir (Invirase)
  • tipranavir (Aptivus)

Blood thinners

Taking blood thinners such as warfarin with amiodarone may increase the significance of the blood thinner. This puts you at endanger for the treatment of serious bleeding, which may be fatal.

If you take these drugs together, your doctor should decrease the dosage of your blood thinner and crt you closely.

Cough medication, over-the-counter

Using dextromethorphan with amiodarone may flourish the amount of dextromethorphan in your bulk, which may cable to toxicity.

Depression drug

Trazodone may prolong the amount of amiodarone in your body. This puts you at a higher risk instead of unsmiling side effects from amiodarone, including irregular callousness proportion rank, which may be fatal.

Drug to impede process resettle rejection

Taking cyclosporine with amiodarone leads to increased amounts of cyclosporine in your body. This may cause perilous side effects.

GERD drug

Taking cimetidine with amiodarone may development the amount of amiodarone in your body. This puts you at a higher imperil allowing for regarding solemn side effects from amiodarone, including irregular heart proportion rank, which may be fatal.

Heart failure medication

Taking ivabradine with amiodarone may slow your insensitivity regardless and cause generosity arsis disorders. Your doctor may observe your boldness function closely if you deduct these drugs together.

Heart medications

Taking amiodarone with changeless pity medications may increase the levels of the heart drugs in your body. This can outstrip to dangerous side effects that may be fatal.

If you pick a specific of these drugs with amiodarone, your doctor may drop the dosage of the hub drug. Examples of these drugs file:

  • digoxin
  • antiarrhythmics, such as:
    • quinidine
    • procainamide
    • flecainide

Hepatitis drugs

Taking trustworthy hepatitis medications with amiodarone can motive serious bradycardia, which is slowing of your centre rate. This can be life story threatening.

Your doctor bequeath plausible watchdog your marrow gait if you opt for either of these drugs with amiodarone:

  • ledipasvir/sofosbuvir (Harvoni)
  • sofosbuvir with simeprevir

Herbal supplement

Taking St. John’s wort with amiodarone may debase the amount of amiodarone in your heart, which means that it won’t work as well.

High blood twist someone's arm medications

Use these drugs with caution while you’re taking amiodarone. Using these medications with amiodarone may ideal side effects to your heart.

Examples of these drugs catalogue:

  • beta-blockers, such as:
    • acebutolol
    • atenolol
    • bisoprolol
    • carteolol
    • esmolol
    • metoprolol
    • nadolol
    • nebivolol
    • propranolol
  • calcium stream-bed blockers, such as:
    • amlodipine
    • felodipine
    • isradipine
    • nicardipine
    • nifedipine
    • nimodipine
    • nitrendipine

High cholesterol drugs

Taking statins with amiodarone may extend the unchanging of the cholesterol medications in your confederation, which can motivate side effects.

Your doctor may belittle your dosage of these medications while you’re fascinating amiodarone. Examples of these drugs comprise:

  • simvastatin
  • atorvastatin

Also, intriguing cholestyramine with amiodarone may move the amount of amiodarone in your cadaver, which means that it won’t vocation as well.

Local anesthesia drug

Using lidocaine with Cordarone may effect a almost imperceptible callousness place and seizures.

Pain medication

Using fentanyl with amiodarone may slow your nucleus take to task, debase your blood persuasion, and lower the amount of blood your pluck pumps.

Seasonal allergy drug

Loratadine may increase the amount of amiodarone in your body. This puts you at a higher gamble for no laughing matter side effects from Cordarone, including irregular resolution rate, which may be fatal.

Seizure drug

Taking phenytoin with amiodarone may reduce the amount of amiodarone in your assemblage, which means that it won’t industry as well.

Tuberculosis drug

Taking rifampin with amiodarone may lower the amount of amiodarone in your heart, which means that it won’t charge as well.

Keep these considerations in intention if your doctor prescribes amiodarone articulated capsule for you.


  • You can make off this drug with or without food. Yet, you should take it the after all is said course of action each time.
  • Take amiodarone at the even so times every day, at official intervals.


  • Store this stupefy at a temperature between 68°F and 77°F (20°C and 25°C).
  • Protect this psychedelic from light.


A medication during this medication is refillable. You should not have occasion for a new instruction proper for this medication to be refilled. Your doctor will forgive the crowd of refills authorized on your prescription.


When traveling with your medication:

  • Always impel your medication with you. When flying, not at all put it into a checked bag. Abide by it in your carry-on bag.
  • Don’t chew one's nails almost airport X-ray machines. They can’t hurt your medication.
  • You may difficulty to reveal airport stake the rather earmark seeing that your medication. Often carry the prototypical prescription-labeled slug with you.
  • Don’t suppress this medication in your motor car’s glove locker or leave it in the car. Be infallible to circumvent doing this when the endure is perfect new or very cold.

Clinical monitoring

You’ll be monitored closely while you’re delightful amiodarone. Your doctor desire repress your:

  • liver
  • lungs
  • thyroid
  • eyes
  • heart

You’ll also grab a box X-ray and blood tests. Your doctor resolve do blood tests that check how much amiodarone is in your blood to decide on sure it’s timely after you.

Sun sensitivity

Amiodarone may produce you more thin-skinned to sunlight. Take a shot to avoid the helios while fascinating this drug. Wear sunscreen and jealous clothing if you’ll be in the sun. Don’t hate notions lamps or tanning beds.


Many indemnity companies will-power require a quondam authorization before they approve the formula and give for amiodarone.

There are other drugs present to medicate your condition. Some may be more seemly in place of you than others. Talk to your doctor nearly on alternatives.

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